Journal article
Chemokine levels and chemokine receptor expression in the blood and the cerebrospinal fluid of HIV-infected patientswith cryptococcal meningitis and cryptococcosis- Associated immune reconstitution inflammatory syndrome
CC Chang, S Omarjee, A Lim, T Spelman, BI Gosnell, WH Carr, JH Elliott, MYS Moosa, T Ndung'u, MA French, SR Lewin
Journal of Infectious Diseases | Published : 2013
Abstract
Background. Human immunodeficiency virus-infected patients with treated cryptococcal meningitis who start combination antiretroviral therapy (cART) are at risk of further neurological deterioration, in part caused by paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). We hypothesized that C-IRIS is associated with alterations of chemokine receptor expression on T cells and chemokine concentrations in cerebrospinal fluid (CSF) that enhance recruitment of T-helper 1 cells and/or myeloid cells to the central nervous system. Methods. In a prospective study of 128 human immunodeficiency virus-infected patients with cryptococcal meningitis who received antif..
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Grants
Awarded by Howard Hughes Medical Institute
Funding Acknowledgements
This work was supported by the REACH Initiative (Research and Education in HIV/AIDS for Resource Poor Countries), a Pfizer Neuroscience Research grant, the Australian Commonwealth Government for the (Australian postgraduate award 2009 to C. C. C.), the Australian National Health and Medical Research Council (postgraduate scholarship 2010-2012 to C. C. C., grant 510448 to M. A. F., and practitioner fellowship to S. R. L.), the Howard Hughes Medical Institute (International Early Career Scientist grant to T. N.), and the South African Department of Science and Technology/National Research Foundation Research Chairs Initiative (T. N.). The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute.